I'm 250 miles shy of 60,000 miles on my 2014 Super Tenere, and a lot of those miles were two-up touring. I won't say it's the best touring bike in the world; I haven't ridden every bike out there and no doubt there are others just as good and better, but it's definitely been the best one for me. Reliability is one of the most important things for me when I'm traveling; nothing puts the bad mojo on a trip faster than being broken down someplace waiting on a repair. I never worry about that with the Super Tenere; I'd throw some clothes in the pannier and leave right now on a trip to Utah without a second's hesitation about the bike's ability to get there, in spite of its mileage.
The bike has its detractors, and I won't even say they're wrong about things like an agricultural feel, or that it's heavy. It's just that those things don't matter to me when compared to the overall performance it offers. It's comfortable for spending hours in the saddle (way more than my old Harley Road King), it's got a lot of pillion room (again, way more than what Harley had on what they considered a touring bike), it has cruise control as standard on all 2014 and up models, shaft drive, and more than enough power at around 100 HP for my needs. It's heavy, but it carries its weight well. With my two knockoff Pelican panniers and a knockoff Pelican top case, I can carry enough stuff for two people for a ten or so day trip without having to stop and do laundry.
This is one of the best reviews of the Super Tenere. It's not a gushing fanboy review, or a review based on how much swag Yamaha gave to the guy. It points out the perceived flaws of the S10, and I think the reviewer is very even handed in his evaluation. If you wanted to consider the Yamaha as a potential touring bike, this review is a good place to start.