I also agree with stromin. Bryson is a great old town, I go there often. There is a great Pizza place on the corner of Depot St and Everett St, good pizza and beer. I usually stay at Gracey Manor (always $66 per night). My path is usually: Bryson to Deals gap (74 to 28 to 129). Then I take Foothills parkway to Townsend then to Cades Cove Rd to eastern Gatlinburg where I pick up 441 to go across the park to Cherokee then a quick ride back to Bryson. It's a big loop that is very curvy and scenic. Stay away from going into Cades Cove with the bike (take the truck or go very early in the morning), you will be stuck in horrible traffic for hours and a very sore clutch hand. Same with Gatlinburg, if you go at the wrong time, traffic will be horrible. If you have time see Clingmans Dome in the park.
I also like to take the Blue Ridge Parkway from Cherokee to Asheville then up to Blowing Rock. It's a good days ride with sightseeing. Beware of the road up to Grandfather mountain! My dad dropped his Harley there last month (again traffic). Mount Mitchel is a good stop but you will need a long sleeve, it snows up there in July. I always bring water and snacks because there is alot of nothing out there.
Cherohala Skyway is a must see. There are some good dirt roads to ride around that area too. Stop at Fontana dam if you have time.
Be sure to be very careful in Deals gap on the Tail of the Dragon. I've had oncoming bikers misjudge curves and end up in my lane on the wrong side of me. Also there are always freshly dropped crotch rockets at the deals gap store. It's fun to get your sticker and it is a cool ride.
I've met tons of Florida bikers in this area. They always rave over all the twisties but must do complain about the "flat spot" on their tires from all the straight line riding in FL.
You will have a great time up there. PM me if you have any questions.
Atlanta, Ga (Chamblee)
1971 Z50A restored 70cc
2006 DL650, Custom pearl orange paint, was baby blue.