Here are some suggestions I made from other threads:
You could spend a few days in Asheville and do "spur" rides each day:
Hot Springs, Mt. Mitchell and environs, Lake Lure and environs.
This way you can spend your days riding with no luggage instead of travelling with full cases and spending otherwise rideable hours packing, checking out, checking in and unpacking, etc.
I could give you a bunch of entertaining routes in the area. Of course. payment for this service can be made in "pints" next May at the Wedge Brewery or Asheville Pizza and Brew or Jack of the Wood or even Barley's.
You could buy yourself a DeLorme Gazetteer for NC and just pick out the squiggliest route. The only downside is the gazetteer isn't real good at indicating where the paved roads become unpaved.
Cheers,
Norm
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Maybe you could blast down I-85 to the SC border and pick up Hwy 11 to North on 130* which becomes 281* at the NC State Line, Take a right onto Charlie's Creek / Camp Pinhook Road* to North on 215* to the Blue Ridge Parkway.
On the way you can see some waterfalls and numerous great overlooks on the way. If you leave early enough, you should be able to catch a late lunch / early supper at the Pisgah Inn near Asheville. Head down the Parkway to Hwy 151* and find your way to Asheville for the night with the highest brewer per capita number of any city in the USA.
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To further the praises of this delightfull little slice of road, I remembered I had this brief video:
YouTube - 151BTDpulloff.avi
The thing is, there are dozens of roads like this in the region (in West Virginia, too). If you like this kind of riding, you can spend a week kissing your mirror. If you want a "journey" the coastal/mountain loop sounds great.
Edit: Watching the video again, I am reminded to warn visitors to the mountains:
"Mind the centerline." I've seen too many close calls when folks come up for a ride. Including my best friend trading paint with a pickup pulling a camper on the way to the Dragon.
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PM me, if I have time when you're here, maybe I can take you on a two-wheeled sightseeing tour.
PS, there's a non-interstate route from Greenville, SC (downtown is woth a visit) via Greenwood, SC, Strom Thurmond Dam, West of Augusta, GA, Wrens, GA, Alma, GA (speedtrap) and Waycross, GA. Also, A1A along the coast on Amelia Island, with a ferry into Jax, continuing with a detour at Daytona is a nice ride.