Speaking from a lot of experience with vintage bikes, it's very, very rare for a motorcycle to actually wear out. Air-cooled bikes may need a rebore and oversized pistons after 100,000 to 150,000 miles or so.
However, the V-Strom has a very modern, liquid-cooled engine, with the potential to last much longer yet. For example, there's an extremely durable coating on the cylinders and pistons, and as long as the valve checks are done semi-regularly, there's very little in the valve train that can wear out. The engine has the potential to last many hundreds of thousands of miles.
Bikes die from neglect and ignorance, not from being used. Things that kill old bikes include:
- Neglected valve clearances (more of an issue on vintage bikes, obviously). Checking the valves seems expensive and/or scary, so the owner just rides it. After sailing through three or four adjustment intervals, the bike slowly becomes harder and harder to start, and doesn't seem to run as well. The owner has no idea what's happening. Eventually, it gets pushed to the back of the garage, and starts to grow a layer of dust...
- Old gas. After three to four weeks neglected in the back of the garage, or perhaps over a long winter nap with no gasoline stabilizer, the gasoline left over in the carbs turns to sludge and clogs the idle passages. Come spring, the bike is hard to start, won't idle without the choke, and the owner just stuffs it back in the garage against the wall... This is somewhat less of an issue with modern fuel-injected bikes, but it's still necessary to use fuel stabilizer for storage.
- Lost carbs. Where, oh where do all the carburetors go? Let's say the owner above understands vaguely that the carbs need to be cleaned. He removes the carbs, takes stuff apart (stripping many of the screws because he knows not of JIS screwdrivers) and eventually gives up, shoves the whole complicated mess into a box, and then proceeds to lose the box. My Freudian theory is that the carb box is a symbol of the owner's ignorance and impotence, and thus eventually his mother comes along and throws it out. I have no idea why, but huge numbers of wonderful vintage bikes are out there moldering away with no carbs anywhere to be found. It remains to be seen whether the same malady will affect throttle bodies and fuel pumps.
- Lost paperwork. Where, oh where are all the titles? Perhaps they vanish down a wormhole and are orbiting a remote asteroid several light-years from here. They're probably surrounded by all the lost carburetors. In most states nowadays, obtaining a replacement title for an older bike is impossible, or very near so. The license branch bureaucrats are under specific orders to keep as many cool old bikes off the road as possible, and they perform these duties with a rare enthusiasm. The joyless take a special delight in crushing dreams and expunging fun.
- Electrical maladies. In a nutshell, electrical connectors are the root of all electrical evil on bikes new and old. Suzuki in particular is especially talented at hiding badly undersized connectors throughout their wiring harnesses, then ensuring that they are open to the weather and thus sure to corrode quickly and bedevil the owner with all manner of interesting, entertaining symptoms for years to come. V-Stroms are no exception -- I've caught several of the same issues in my 2002 Vee that I'm very familiar with on Suzukis nearly 30 years older. For example, the stator connectors, the connections to the headlights, that goofy little connector in the top of the starter relay that's expected to carry up to 30 amps... these are all familiar enemies. Speaking more globally, it takes a lot of skill and experience to track down electrical issues, so many owners just give up at this point. Tired of the bike's appetite for $200 stators and regulators, they never bother to correct the simple root causes, and the bike goes to the back of the garage. Or envision the vintage bike with a no-spark condition. They follow the troubleshooting list in the factory manual, look up the price of a $750 igniter and give up, never understanding that low voltage at the coils, or corrosion in the key switch connector was the real problem.