On the way south.
I think you would prefer secondary roads instead of Interstate Highways.
If that is so, consider this route. We start at the Peace Bridge, where
I have arranged that eastbound Suzuki motorcycles pay no toll!!!
Get onto I-90, and follow it past the big right turn toward Erie PA. Get off at Exit 57 and follow NY-75 southbound, which connects with US-62 southbound after about 3 kilometers. This US-62 is a favorite of mine, and I have used it a lot.
Your last chance for Tim Hortons is in Gowanda NY. US-62 goes through Amish country, and you may encounter horse-drawn carriages. I choose to pull in the clutch and run almost silently past horses, because I do not want the horse to be startled (or perhaps spot a chance at freedom) and climb onto the motorcycle. Suit yourself on that issue.
US-62 enters Pennsylvania, and follows the Allegheny River for a while.
The scenery is very pleasant, and the road surface is pretty good.
Here is a "long cut" you can take if you want: at Tidioute PA, get onto PA-127, which wiggles and eventually returns you to US-62 after almost ten kilometers.
Here is a short cut: When you can make a left turn onto PA-965, do it,
and you will shorten the journey by about six kilometers.
This road also returns you to US-62, just before you reach I-79.
I take I-79 south to Sutton WV, then US-19 south to Beckley WV (observe the 50 MPH limit in $ummer$ville), then I-77 south to I-81, where I turn WEST and follow I-81 SOUTHbound for two miles to Exit 70, and there I pick up US-21 in the town of Wytheville Virginia.
Let me tell you, this US-21 is a treat! It wiggles its way up a mountain and down the other side, and it is a joy to ride. It shows you all sorts of farms, rural villages, and pleasant hillsides. After a couple of hours, it brings you back to I-77 southbound, near Jonesville North Carolina.
At that point, you can decide to make time on I-77 or continue on US-21 to Statesville NC, where you face the same decision. If you stay on US-21, it will keep bringing you back to I-77 until finally it merges with I-77, 33 miles from South Carolina.
I know some more wiggles in and south of South Carolina,
but you didn't express interest in those states.
I hope you enjoy your ride.
P.S. All tolls are free for cars and bikes crossing
the Peace Bridge into USA. I bet you knew that.