The entire Monongohela NF area is great...lots to do.
Here's a route I've done along your path...
16 from Marietta down to Gauley Bridge/Fayetteville (Hawk's Nest SP is great twisties!), then 60/64 down to Lewisburg. You can see the Civil War sites there, grab some lunch in some cool historic restaurants, or ride over to White Sulfur to check out the Greenbrier bunker (under the resort for congress). Riding Kate's Mountain is good while you're there, the comm. equipment for the bunker is at the top of the hill.
From there, ride 219 up to the Radio Telescope. Fantastic road! Lots along that route, 2 civil war battlefields at least. Ride up 219 to Elkins, catch 33E to Seneca Rocks. 28 north to the Dolly Sods area, ride up to the top, it's beautiful up there. 42 up to SR50, then 50west....some epic twisties in there.
50 meets 250 past Grafton, a great road to ride back up into Ohio.
That's a really great route with a lot of stuff on the way.
Never met a dog I didn't like, a machine I couldn't break, or a woman I couldn't tick off.