What are you thinking about. A ride out to Gettysburg then to Pittsburgh, up to Erie, then over to I guess the Grand Canyon of Pa (Leonard Harrison State Park), down to Allentown/Easton area, then to Philly, then back to Lancaster?
Also are you going to be super slabbing it all the time or is this going to be a back road tour?
Also were you thinking of camping or staying on a hotel? A hotel at least some time during the trip will allow you to get a shower and get some clothes washed if the tour is going to be long.
If people start tossing ideas into the "hat", you should be able to get a good route down.
I know there are a few places in pa that are good tours, but they are not Iron Butt. More or less a day or two trip.
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