I asked this same question a year or so back and got a lot of responses from my "king-sized" brethren suggesting that the Wee is OK - unless you're going to do a lot of 2-up.
I only rode a Wee for about a mile or so, but was pleasantly surprised by it. Of course, that's coming off a KLR with about 30hp - the Wee is about 60hp, IIRC.
I ended up with a Vee because that's what I found used. I don't want for more power, but I rarely ride use all it has to offer anyway. When it's time to look at a new bike, I'm going to look hard at a Wee for the increased gas mileage, smoother running, and ABS.
Oh, 6'4", 290#, 33" inseam. I still felt a little cramped on the stock Vee seat, so got a Suzuki 'tall touring saddle.' My legs, hips, and knees are a lot happier, but butt's only a little happier. At only about $150, it still seems worth it.