Just a quick note on the Karoos. I ran across another thread, either here or at ADV Rider, on the noise of the Karoos compaired to the TKC 80s. For a knobby, I think the TKC's might be the best dual-sport with the Anakees a great 80/20 tire with better wear and on-road manners. I am currently running Distanzias (what was on my last bike as well), but have a set of TKCs waiting in the garage.
Good luck in your choice - I think any of these tires will work well.
"This above all: to thine own self be true". - (Hamlet, Act I, Scene III).
'05 DL650 - Textured Flat Black
Rifle Screen and KTM mirrors
Bill Mayer seat
PowerPegs (lot of grinding to install)
+1" rear link and ProTaper ATV Hi bars
SW-Motech guards/crash plate
GI Pro w/ATRE
'97 BMW F650 (gone)