I used the 17/43 for years and liked it. I mostly ride two-up and bags loaded using highway going to and from the mountains.
My last episode with sprocket change was an experience (long story) but ended up going with a 42 rear due to the amount of highway I was planning on doing in the future. Ultimately I will probably go back to the 43.
2012 DL1000 Adventure (Tinkerbell)
PC-V, TRE, CR8EIX , ECM, K&N, RDL, PR4, PC-8, EB H4, WERKS, Madstad 22", 17/43 gearing, AdventureTech: Fork brace, shelf, mirror extenders, SpeedoDRD, wheel spacer, Head's-Up voltage monitor, Goldwing pegs, Sonic 1.1, Wolo Bad Boy, ExTuff Helmet Hook.