Enjoy your ride, Tim. The only specific guidance I can offer is simply this:
Avoid the Ambassador Bridge. This is a teeny constraint, and may guide you to the International bridge from Soo-to-Soo or the Blue Water Bridge at Sarnia, or even the Peace Bridge to Buffalo. Each of these is fine. The problem I have encountered at the Ambassador is the same, again and again: INCOMPETENCE coupled with total unconcern for politeness, expediency, or a pleasant attitude. My dog's kibble was confiscated, reason refused. I got an Ohioan's documents back with mine. I was questioned for an hour, on December 24 fer goodness sake.
And don't use the tunnel instead; motorcycles are forbidden there. Again, reason unstated.